I got loads of things packed into December and now I am here blogging…
Fuck it, here’s another entry.
The top most important issue is the arrival of Wasteland 2 Beta. And oh mine, I got a big shock that despite nagging that much that long… the game is really not that suitable for an old fan like myself. There are many things… the display pics ain’t animated for NPCs, the locations are rather lowly populated and some scenes don’t even make sense! And I was paying very very much attention on the travelling at the world map for random encounters which will make or break the game…
Basically, it’s good the beginning of a combat has now a more stylish introduction than a childish-looking bullet-shots display, but the word ‘Encounter’ may block the initial damage report done on the field if you start shooting first to trigger the encounter. That’s still ok… but best if they can freeze action while the word is still there.
The major problem of combat is, unlike Fallout 2, I noticed very very low frequency (if any at all) of naughty lines made by NPCs. And the battle field can be pretty squeezed in random encounters, plus there seems to be only ONE combat music for the entire repetitive moments of bloodshed throughout the game! Also there is no special effect for criticals made after Fallout 3’s for Wasteland 2, and those ‘huge’ display pics of foes which have NO animation were blocking too much of the right side, that hilariously is constantly telling us how tiny those display pics of our party members are at the bottom!
Our members’ tiny display pics have no animation but have included even their waists! That renders each display pic a blur portray of self on field. Which is, if two chaps wear the same color, you can’t tell them apart conveniently… you can’t even easily tell the sex. Why can’t we just have their faces instead?
The funniest thing is, a lady raider’s portrait has a male voice!
That’s so ‘beta’!
Add to that, the names should really be ‘upgraded’. ‘Myron’, ‘Charon’ and ‘Sulik’ are more stylish than ‘Tooth Smasher’, ‘Night Waste’ or what ‘Cold Blooder’… That’s so… childish!
Not only that, unlike Fallout 2, you can’t ever get those team-mates to communicate. And when the team does talk to anyone, the speeches are all in the same white, and it’s easy to be confused who’s really talking. This is uncool because I expect more talking heads and more interactions in-game with those team-mates since Fallout 2. Even JABIA has team-mates who can make noises at varied situations! And even that I thought that wasn’t enough… Now Wasteland 2 is giving me worse than Fallout 2!
I am not interested to have a mid-90s gameplay…
And unlike Wasteland 1, we can create ONE lead character and to choose a pre-made 3 others in Wasteland 2, and unlike JABIA, the choices for beginning NPCs are relatively few. And the customization is also pretty limited. I totally hate the idea of a portrait representing them on field instead of the current norm in current games that uses 3D animation for those avatars reflecting immediately what glasses and caps and masks they are wearing.
And the use of firearm skills is really hitting raw nerve. Despite my suggestion, Wasteland 2 doesn’t differentiate between melee/unarmed and firearms in that anyone who can fire a sniper rifle at level one can know how to basically load the magazine, pull the trigger and aim at point-blank with a pistol. How is it possible that I can fire an assault rifle when I don’t have the skill to basically send a bullet flying with a revolver? The point is, if you choose to unlock any firearm skill, all firearm skills should be unlocked for level 1!
I am pretty particular about this because I was first trained to fire off from a fucking heavy revolver then progressed to assault rifles then to sniper rifles. We learned the basics for loading, aiming, the need of the safety mechanisms, then to deal with the peppering style of assault rifles, then to the sniper rifles which need extreme precision for decent performance.
In a way, if you can handle an assault rifle you can also handle a shotgun at basic level.
So it completely makes no sense to me…
One of the shocking discovery during observing Wasteland 2 Beta is the print of ‘750 water’ at oasis. If that means the reserves, if the reserves of water won’t regenerate over time… that means we’d have a problem with in-game time to explore and do whatever we want and go wherever we fancy whenever we fancy, so there is a time limit hence subtly set with the water reserves to finish the game. This is real bad news…
I have also noticed that of the couple of various gameplays by various chaps, random encounters are infrequent. It is important to keep loots little and ammo scarce, but it is only because we should be able to earn those resources from random encounters… by choosing to murder merchants, to rob the slaves and civilians, to kill those raiders…
The problem is, I see many rushed into battles to discover their ammo couldn’t last to the end and they couldn’t opt to make any changes to this destiny before those battles without roaming the map and exhausting water reserves. In a way, this ‘open ended’ game is restricting those options subtly. And it’s really strange that icons for hidden oasis and perhaps other unimportant locations are so huge when they should be just dots!
The promise of a world map similar to Mount & Blade is rather… not seen in Wasteland 2. You don’t see other random creatures running about which you can avoid or purposely chase after to engage as in Mount & Blade, and you definitely don’t have such huge icons of oasis springing out to congest the path. And I feel very constricted especially when I recall the world map of Fallout 2.
And will those radiated clouds be randomly blown away or moving around the world map?
I am not sure what I can expect for Wasteland 2… And after I have watched the gameplays on Youtube, I must say I am kinda… disappointed. You can’t even shoot those monsters’ legs to slow them down as in Fallout 2. Those monsters will just dash out like some super heroes from nowhere right next to you instead of appearing in random waves… That makes combat even more boring than Fallout 2 when you could target legs or heads or arms to make your enemies drop weapons…
I don’t see how I can make a monster falls down by shooting at its leg and reward myself a big laugh in Wasteland 2…
I still see also that 2~3 miserable raiders dare to stop a team of 5 rangers for tolls…?!
Will Brygo Faran go solo to Needles asking those jerk gangs for protection money?
Many locations are so pitifully lowly populated that I am wondering… where are the graves? And this is since Wasteland 1! The Agriculture Centre with all those food farmed by farmers have a population of like… less than 20, and no children… and I don’t see they have any rest rooms or toilets… or even a workable transport using simple motor or ‘bicycle technology’.
They have no need to fuck?
They don’t even have a guard dog?! Do they?
Then Highpool is crying for help on the radio… as if there is a warzone… I haven’t watched the Highpool gameplay yet, but I SERIOUSLY doubt the ‘war’ will have many many corpses laying around and there is a decent resistant force to have lasted Highpool that long, and I don’t even expect the number of raiders or monsters to be more than 10 each encounter!
I also noticed a couple of bugs, and realized that many locations are too dark making the gameplay like some mouse exercises at each map scrolling around the screen for clickable finds. The insects didn’t even attacked those trapped scientists at the Centre, there is a chap who just won’t stand after he shot the rabbits and is turning directions in a rather unnatural manner… squatting.
The icon to exit to world map is simply hideous because it is so huge and so childish-looking. OMG~ Most fans who have waited since 1989 for Wasteland 2 would be now adults! And the children nowadays would be comparing Wasteland 2 to Fallout 3~ We cannot have Wasteland 2 that seriously mid-90s!
One major issue with Wasteland 2 is the lack of Easter Eggs and everything funny, naughty and ‘tasteless’… It’s not rebellious enough, and it implies Brian Fargo might have seriously aged mentally… … I can see the team trying very hard to make it ‘beautiful’, but the gameplay sucks because it’s not as interesting as Fallout 2~
Which is, for the first 1 hour of gameplay, they expect you to go through the normal customization people are now used to at Skyrim, Brink, Saint R, and so on… when customization in Wasteland 2 is really kinda limited relatively. Boring eh~ Then you expect people to go through the Wasteland 2 beginning right after they have been through the interactive cinematic of Skyrim, Fallout 3… and Wasteland 2’s intro is simply a chap briefing the guys with another moron constantly digging behind him. Argh~
And obviously… all my nagging for the perfect sequel has gone nowhere… …
Wasteland 2 is going to be boring as Hell despite the praises it is receiving so far…
Nothing new. Other than the graphics, it’s probably worse than Fallout 2. Brian seems to be ‘dry’… … in my humble observation. So far, the gameplays on Youtube should be around 2hrs. When Brian succeeded in making the production of Wasteland 2 possible, I had very high hope on the sequel. Wasteland 1 was a game of its time with incredible amount of energy invested in breaking rules and raising new ideas…
Wasteland 2… reflects a Brian now an aged man trying desperately to catch up and be relevant alongside Fallout 2.
Gaming world is merciless… If Brian cannot make it… people may still buy Wasteland 2 for childhood’s sake, but gaining more fans from existing children will be an issue. And it’d lose fans like myself over time, and the franchise to depreciate into just another RPG. It’s the same as Fallout 4. If Fallout 4 doesn’t come with improved in-game economy, and more realistic behavioral cycles and so on… Even for Fallout New Vegas, with random encounters gone… I see no point in collecting the Ultimate Edition.
New Vegas is boring… NOTHING NEW, the DLCs are crappy. That’s why I did a video for training using Fallout 3 and not FONV. The arsenal in FONV is ridiculously messy#1. It’s just another walk here and there and VATS-the-fuckers-out game. It was fun to see the 3 rockets of ghouls flew off, but that’s all… We couldn’t even hire a maid or bodyguard for our homes, and there are no thieves or raiders who’d disturb the homes anyway… FONV is pretty sloppy.
It started out as a cash cow with horrendous bugs! That showed.
[Just watched this… this guy’s freaking funny! LOL!!!]
I supposed Brian wanted to build Wasteland 2 into glory… but if this is really what I was watching in Youtube…
This is not funny.
Wasteland 2 is not funny. People will remember that funny Myron, and they will be rushing into yet another boring combat repeating the same options in Wasteland 2, and… the game ends with those crazy memories of Fallout 2.
You remember how that fucker died in flame… dancing?
You remember how that moron’s torso got busted by a pile of leads?
You remember that ghost at Den?
You remember that stupid Talking Head?
So far, I don’t see one decent cinematic… … after 2hrs of gameplay. We don’t even have any animated portrait. It’s just another map, another day loading and pressing shoot, and getting exps… and kiss your ass goodbye to Marcus from Broken Hills. Can you even steal in Wasteland 2?
Haven’t seen any gamers did that~
I’m curious to see what Highpool has in store… Will I see a mad ass firing in dramatic fashion his huge nasty mini-gun in an explosive showdown with the raiders… and dying a hero in dramatic fashion with powerful sound effect as the team moves into Highpool?
Will I see a car being drilled into a huge display of mega fireworks?
What will I get to see?
I decided not to nag anymore at the team. I’d follow through those walkthroughs in Youtube… … and pin my hope on Fallout 4. Maybe Bethesda will be as stubborn… and run the same old broken records. But as a gamer, I can always choose to play something else.
From the look of it, Wasteland 2 is likely to be a wasted attempt and really become the ‘grandfather’ of Fallout series. I very much doubt it is due to short of funding… but the ideas have run out on Brian’s side. I think Brian can understand people don’t want portraits, people want animated figure heads… for instance.
Say… will that computer the team is supposed to fix be blown up after 2 failed attempts?
Then will there be a secret tunnel exposed for a new mission?
Why isn’t there a motherfucker boss of those rabbits? Pikachu?
And remember those huge mega tomatoes launched at you in Wasteland 1? Why isn’t there a launcher of those tomatoes at those rabbits to be used? That’d be fun…
If that chap has been shooting at rabbits for practicing… Where can we find his personal store of ammo?
Do you see a monstrous carrot around?
Where did those raiders sleep? Where are the prostitutes?
Why do we need to radio in for promotion if there is no ranking to be ‘bestowed’? Such as…
“Oh Echo One, you have done a fucking great job, but you killed that old fatso, people now called you ‘XXX’, but congrats, your team has reached ‘rookie/expert/elite/the ace (bla bla bla)’ status (hereby granting them a bonus for whatever, or even an award…)”
The nice part about radioing in at Wasteland 1 is to check the promotion. Radioing in at Wasteland 2 should be done when the party has done something heroic or super for promotions and bonuses and such with the ‘leader’ as a benchmark for growth. Instead, it becomes a ‘repetitive’ event that can be totally wiped off to save time and bytes… You almost can certainly expect what to hear from the other side of the radio for the same promotion message… till you decide to quit playing.
That’s gonna be very very boring.
“Great you have radioed in to check your status, rangers! You have pumped the Scopitron so badly that our general wants to see you so badly for a promotion. A Meson Cannon is waiting for your collection! And you have now this perk that access…”
I’d be happy if the commander’s sexy mistress will now want to travel along… half naked. LOL~
Or at least…
“Congrats, rangers~ Your scores is impressive and at (now) level 9, you are the ‘Big Daddy’ (Kingpin, Giant, Peanut, God Fathers, whatever) of the waste.”
There are many ideas you can add in to Wasteland 2, but the team seems to be pretty dry… so this traditional radio in for promotion part becomes an white elephant ready for the slaughter… …
Something that I find funny is that the party can begin with a new NPC recruitment right away before hitting the world map at Ranger Citadel… That recruitment should be available IF the party suffers any casualty upon returning to the citadel.
Why can’t I just recruit her at the beginning? Why not?
Why must I travel in a team of 5? Naturally, 90% of the gamers will take her along given the beginning weakness of the party.
Last but not least, I am glad to see Wasteland 2 finally possible, but I seriously perceive the need to critically upgrade (or mod) the game. Hopefully they have withheld all the greatest of great ideas from the beta and it’s not merely for bugs-testing, and Brian still has time… and his last chance to do up the game before the final version. I hope he doesn’t forget that he has huge competition for the same gamers’ chips.
There is a serious need to redo the ‘introduction’… to make it hot and juicy.
The party can venture into the world map, hit an encounter right away with a ghost town of zombies with a kid called Leon running away with a doll called Ashley from ghouls… or geese… and there could be banners to be read yielding clues and hinting future quests in the ghost town, and with impressive music. And with high luck, you can even find something valuable in a ‘wishing’ well.
This game should be just another ‘chores-in-a-bundle’. Skyrim is a major fail because it has many many quests, but those quests are poorly designed… and minute in purposes and don’t shine. Excusing the bugs, Skyrim tries to excel in beauty, but… many locations are boring modified replicas of such ‘beauty’. I didn’t complete Skyrim basically because it’s very boring… I don’t even feel like exploring those many many locations.
Not to mention, the way you ‘grow’ in Skyrim is shamefully ridiculous. How the fuck you become more powerful by making leather jackets? LOL?!!!
Fuck you, Skyrim!
I can become a lvl 20 veteran fighter killing nothing but by polishing boots, stealing and mixing chemicals with shooting and melee skills at lvl 1 when the system will match me with creatures of toughness at lvl 20.
So fuck you for wasting my time, Skyrim~
I seriously don’t understand what’s going on in the skulls of game-makers nowadays. But Skyrim is not without merits. It has many cool ideas… such as marriage which is loaded with bugs and a hooking up process hilarious to the max, and a wand that attacks you by turning you into rabbits and such… But the fail is overwhelming, and I didn’t complete the game…
How time flies…
1989 till now… it’s really a long time.
I used to wonder what great relationship I’d have with a wonderful girl… …
I grew up… and realized girls are such major disappointments.
So now… Forget about relationship… just have a good fuck, dump and run after the next… … Why get hurt when you can have all the fun?
Sadly, I can’t be blind like the mortals… … I just can’t lust after the illusion of ‘family’, ‘marital status’ and bla bla bla… …
And fuck social norms.
At this period of time when I am busy with a new venture, Cat was back yet again with her ‘remorseful’ reflection (again) telling me how she had done wrong (again), how it could be our ‘communication issue’ and bla bla bla that she should have handled proper… …
I know what she wants… … or was hinting at.
It’s not the first time…
She went around spreading lies about me, attacking me, telling people how bad I was… So did my own sister… who kinda thinks she is my greatest competitor at home since young, always trying to boss around when she is really not that great.
Cat did all those attacks on me partially because she didn’t want other ladies around to favor me, partially to protect her own inferior complex for making all the nuisances and killing our relationship by making me as low as possible. She knew I am a good guy, she knew I had been good to her and had tolerated her nonsense beyond normal man could… Whenever she is in big shit, no matter how horrible she had attacked me, I’d be the one she found for help, and I’d usually help her.
In a way, I hate her ‘friends’. They not only are immature idiots who tried to be smart alecs, but reinforced her craziness which… allowed her to do what eventually destroyed her, and hindered my progress along the way. Now she is stuck. And my family hates her to the core.
To this day, I still try not to be too bad to Cat.
But reconcile is impossible. She knows what she has done.
She knows how I had been to her and she had been to me instead. But it’s not about not forgiving her… she has become a threat to my existence. I don’t mind still helping her a little. But she can no longer enter my life ever again.
And I don’t care what those fuckers around her think of me, especially that KPO Lyn… and her childish low-taste boy boy. Lyn is not a bad lass… she’s just unreasonable and childish, and she’s kinda crazy.
And it’s definitely not because of Kate‘s reappearance. And definitely not because of the other women… …
I love Kate. Kate has been hiding in my heart for like so many years way before I met Cat.
So after telling the world how bad I am, and attacked me this and that and all those smart alec lies and ferocious hurts bestowed upon me… Cat was telling me the same old bulls that she shouldn’t have done this and that.
I felt sad for her… despite all the damages I suffered.
Without me around her, she’d likely get into serious trouble.
She’s no longer young and mesmerizing… hopefully this will help her stay in a more peaceful state of life.
Kate is also aging like nobody’s business… Hilary too.
I got a new date later… that I suddenly find myself no spare time and mood to attend.
It’s definitely not I am not horny… I just want to finish things at hand. And… I have no short of cunts for the fucking pleasure to miss a few dates… a few girls. Let’s just say I am officially declaring a holiday for the dick. My last check at the drawer showed I have sufficient condoms available.
Always, whenever I made a new girl friend… I have hoped that suddenly the date will bring her friend… and her friend would be her… … But in reality, no matter how much my heart wants to, the brain warns against it.
It’s not because of what infidelity or social norms.
Right now, at this crucial junction… defined by Emeritus Goh as what Inflexion Point, I must concentrate. Part of me wants to help Kate to grow up and appreciate what I am doing; part of me knows very well, she isn’t going to be on par ever.
She is merely a mortal.
If I can move events in time… I might be able to avoid a direct fight with Kate. She knows I have her in my heart, but she is… not really going to understand what I am thinking… and doing. She can’t see what is to come… as Mah Bow Tan can’t. A lot of things are at stake, and her silliness can mess things up because I do care about her.
I do care about her… but I can’t do anything for her to change the destiny.
Eventually, she will be facing the same end as ole Siping and everyone else on this moronic cursed island.
Asian cunts… … I don’t want Asian cunts. I don’t need the silly version of ‘love’ from usual cunts. In a way, I am only looking for one.
And if I can’t find her… it might be better to remain sanely single in serenity.
Because of her… I fucking hate God. It’s probably why I felt the strange anger towards churches when we first met. I can still remember peeping at her through the classroom window with my head pressed on the desk… She was so funny… … The way she walked… the way she stood… the way she swung her fist and made the kick and stretched… the way she talked to me in her shaky voice, looked at me… the way she blushed… … and when she gave me the numbers…
I also remembered… Lee Kuan Yew has a son, Loong would become the PM roughly around now… and situation will be collapsing soon partly thanks to Loong… I was… figuring all these for many many many years over many many many times…
I love a married her.
She probably forgets about me already.
At such a junction when Loong’s now fixated on the cross ready to be roasted, I kind of have more time fumbling through sweet memories of Kate. I was very very hesitant to call her… now when I will call her… I can no longer do so.
This is the last mile for PAP… and the lull for me to shake legs at the sideline and stay out of attention is going to be over soon. Very soon, I’d be busy fighting for the last hope of Singapore. At last… the time is coming… as so calculated for all my life… …
I lust after Kate… but I also lust after power… and more… I lust after a miracle to be stated in the modern history of mankind, of a great legend… made possible by me… by my rise to power.
I have ‘designed’ this story all those while.
“Nobody… however smart… could have seen it coming…”
I was hoping Kate would be single when I could meet her again… when the situation will be now on track. I kept her photo wherever I went in my wallet… with whoever I dated and fucked… …
It’s a lingering thought of an impossible relationship… because she chose correctly. How the fuck can any mortal understand what hack I am doing and will be with me through whatever all the fuck years…? The love story of an alien with a human is destined to be disastrous. I’d never be happy… just to be another ‘worker’ or economic slave working as a manager… for a fuck condo… for a meaningless life of pleasures and waiting to die as Mr Lee is now… and to rot without a majestic fight… …
If I must die… I must die only in the grandest brawl for the most honorable goal.
The New Father of Singapore… It is the dream since before I even attended primary school…
It sounded very crazy… even just a few years ago, when Loong even thought he could just pull any shits into parliament. He is totally out of touch. But I did ‘sound the alarm’. Who in PAP can blame me? Even Josh knew…
I already did everything I should have done for PAP… and expected that everything will change nothing.
What sounded crazy is becoming so real…
Time to prepare for takeover… Basically…
Just push every trash to Low Thia Khiang, Nicole Seah… bla bla bla. They really think they can still lead by trying to be ‘diplomatic’ and part of a ‘Singapore Idol Contest’? What killed PAP will kill those incompetent wannabes… Then…
I hope those flowers Nicole and Daryl and chaps gave out at Little India won’t just end up in bins…
Kate… … If only she is not just a typical Singaporean mortal cunt… … if only… …
Hi Mr God… fuck you~
孩子就是孩子……小动作非常多，没一件实用的。在紧要关头，在可能的生死存亡关键时刻，在小印度当时新加坡人可能需要支援的时候……一心希望哄百姓支持投她票的尼可虾选择了‘投机取巧’的行为。也就是临阵的‘You die your business’策略龟缩了，然后到小印度送些没用的花……亮亮相，搞个事后诸葛亮的筹款……
那个Seah老头子称的什么知名评论Leong Sze Hian等等，说穿了……就是要对行动党放话，攻击政府逞英雄，再说些有的没的让网上愚民爱听的，然后集结成势……
[This chick… she’s really sexy in the way she expresses herself. Amazing charm… Look at the way her video is made… and her performance. Salute!]
[Important Note 2013] For own bio-chem understanding…
The essence of this finding is a series of molecular events that enable communication inside cells between the nucleus and mitochondria. As communication breaks down, aging accelerates. By administering a molecule naturally produced by the human body, scientists restored the communication network in older mice. Subsequent tissue samples showed key biological hallmarks that were comparable to those of much younger animals.
“The aging process we discovered is like a married couple — when they are young, they communicate well, but over time, living in close quarters for many years, communication breaks down,” said Harvard Medical School Professor of Genetics David Sinclair, senior author on the study. “And just like with a couple, restoring communication solved the problem.”
This study was a joint project between Harvard Medical School, the National Institute on Aging, and the University of New South Wales, Sydney, Australia, where Sinclair also holds a position.
The findings are published Dec. 19 in Cell.
Mitochondria are often referred to as the cell’s “powerhouse,” generating chemical energy to carry out essential biological functions. These self-contained organelles, which live inside our cells and house their own small genomes, have long been identified as key biological players in aging. As they become increasingly dysfunctional over time, many age-related conditions such as Alzheimer’s disease and diabetes gradually set in.
Researchers have generally been skeptical of the idea that aging can be reversed, due mainly to the prevailing theory that age-related ills are the result of mutations in mitochondrial DNA — and mutations cannot be reversed.
Sinclair and his group have been studying the fundamental science of aging — which is broadly defined as the gradual decline in function with time — for many years, primarily focusing on a group of genes called sirtuins. Previous studies from his lab showed that one of these genes, SIRT1, was activated by the compound resveratrol, which is found in grapes, red wine and certain nuts.
Ana Gomes, a postdoctoral scientist in the Sinclair lab, had been studying mice in which this SIRT1 gene had been removed. While they accurately predicted that these mice would show signs of aging, including mitochondrial dysfunction, the researchers were surprised to find that most mitochondrial proteins coming from the cell’s nucleus were at normal levels; only those encoded by the mitochondrial genome were reduced.
“This was at odds with what the literature suggested,” said Gomes.
As Gomes and her colleagues investigated potential causes for this, they discovered an intricate cascade of events that begins with a chemical called NAD and concludes with a key molecule that shuttles information and coordinates activities between the cell’s nuclear genome and the mitochondrial genome. Cells stay healthy as long as coordination between the genomes remains fluid. SIRT1’s role is intermediary, akin to a security guard; it assures that a meddlesome molecule called HIF-1 does not interfere with communication.
For reasons still unclear, as we age, levels of the initial chemical NAD decline. Without sufficient NAD, SIRT1 loses its ability to keep tabs on HIF-1. Levels of HIF-1 escalate and begin wreaking havoc on the otherwise smooth cross-genome communication. Over time, the research team found, this loss of communication reduces the cell’s ability to make energy, and signs of aging and disease become apparent.
“This particular component of the aging process had never before been described,” said Gomes.
While the breakdown of this process causes a rapid decline in mitochondrial function, other signs of aging take longer to occur. Gomes found that by administering an endogenous compound that cells transform into NAD, she could repair the broken network and rapidly restore communication and mitochondrial function. If the compound was given early enough — prior to excessive mutation accumulation — within days, some aspects of the aging process could be reversed.
Examining muscle from two-year-old mice that had been given the NAD-producing compound for just one week, the researchers looked for indicators of insulin resistance, inflammation and muscle wasting. In all three instances, tissue from the mice resembled that of six-month-old mice. In human years, this would be like a 60-year-old converting to a 20-year-old in these specific areas.
One particularly important aspect of this finding involves HIF-1. More than just an intrusive molecule that foils communication, HIF-1 normally switches on when the body is deprived of oxygen. Otherwise, it remains silent. Cancer, however, is known to activate and hijack HIF-1. Researchers have been investigating the precise role HIF-1 plays in cancer growth.
“It’s certainly significant to find that a molecule that switches on in many cancers also switches on during aging,” said Gomes. “We’re starting to see now that the physiology of cancer is in certain ways similar to the physiology of aging. Perhaps this can explain why the greatest risk of cancer is age. ”
“There’s clearly much more work to be done here, but if these results stand, then many aspects of aging may be reversible if caught early,” said Sinclair.
The researchers are now looking at the longer-term outcomes of the NAD-producing compound in mice and how it affects the mouse as a whole. They are also exploring whether the compound can be used to safely treat rare mitochondrial diseases or more common diseases such as Type 1 and Type 2 diabetes. Longer term, Sinclair plans to test if the compound will give mice a healthier, longer life.
No wonder… No wonder why my cell age is so fucking young!
#1 Bugs bugs bugs! Huge bugs! You have the weapons, you don’t have ammo~ and many cool weapons are available only at the last quest which you have to loot from the fallen. FONV is merely a map with a super rusty shade for gameplay. Things like roving merchants, some over-grown sheep and such do help. But over all, FONV is boring! Especially when it removes the random encounters idea in Fallout 3 when Bethesda should improve it.