Went back to the barber at Geylang and can’t say he didn’t do a good job… that was why I kept going back. This entry is going to be pretty challenging due to the need of contents to go with so many pictures.

I was thinking about political reforms… again. I know very well Singapore is not yet ready for a major reform; at least the society will need a major ‘haircut’ to the basis, to reshape things up from scratch and then… Whatever it is, Education must link to Manpower, Manpower must link to social issues, and we also need reforms for Health Care that is currently impossible… because we lack talents, and talents can take forever to reach power. We have a couple of advanced medical developments on the loose soon, this will target the aging population readily… this will need financing. The basic problem about aging can be solved relatively with ‘anti-aging’ compounds.

If people can be revitalised after they have aged, supposedly they can function… work longer and work meaningfully even in manual positions.

It’s power-play now that bugs me. When there is a need to look into reforms… it’s very disgusting that needed reforms will be hindered by mere power-plays, but politics is after all… power. There is a need to ‘educate’ this moronic world what sort of leaders will be needed to safeguard the future. Before that… snobs will still rule the day, and there will be no peace… no future.

This is Scope… If you share this belief of mine, so you are not that alone. Merit-based governance is horrible as many talents are wasted… Talent-based governance must replace the shit left behind by the past.

But I fear the old success story will blind the current generations long enough to deprive dire need of reforms.

Remaking economy is not a slogan… and it can only be possible with talents… real hardcore talents in governance. This element is precisely what the current government is lacking.

If there is a future… it seems unlikely a fight is avoidable.

Seriously, I prefer to quit.

[36大寿的祝贺] 爷我的生日将近……真是难得~一般人生有几个36……莫名其妙,有惊无险又一年。老男人的生日愿望其实很简单……在这里不提了。对于未来,有些不敢指望……

不知道今年的生日又会如何庆祝?生日这种东东是过一次少一次,所以每到生日,怎么过就头疼。也许人长大了也就讲究了。生日不愿留白,难得灿烂一下也不错的。反正开心就好吧……

每个人都有生日,降临在人间的日子是特别的。今年的生日过了还有明年的,明年的还有下一年的,每一次都特别,每次都希望快快乐乐的,每次都有心愿,每次都往眼前看去。在这么浪漫的日子,我觉得没有什么会比自己最重要;在36年前,一个娃娃诞生在这世上就注定了将迎接这36次的生日。美丽的灵魂和一浪漫的天在永远夏天的小岛上能有什么火花,那也只能拭目以待。我……好爱自己,因为自己陪着自己要走天长地久,因为自己要伴着自己海枯石烂,因为只有自己最爱惜自己;这世界上,只有自己疼惜自己才是最幸福的。

在这么一个特别的日子里……成长是永无止尽的才是。若人生是一场梦,但愿这个梦永远不会醒。

加油吧,亲爱的我!

[千元的谜团] 今天发生了怪事儿……弟弟房间的一千多元不翼而飞,所幸并没有怀疑我。老妹说我这个人对钱没有概念……但我还是有些不安。毕竟钱是在家里失踪的,而女佣发誓不是她拿的,所以老妈也无奈。其实就算是女佣偷的,只要放在自己知道的地方等需要离开时再设法取走也可能。弟弟的钱应该是老爸托他还车保险用的。

但老妈说的好像是老弟还自己保险用的,而且还存了一段时间。我也不知道。反正一千多元在家里不见了,对我而言真的不可思议,顿感不安,因为家里应该是最安全的地方。如此,我房内什么值钱的东西也难保不会突然消失。老男人不打算怀疑小猫……她不大可能跑到老弟房里又知道哪个抽屉有钱而顺手牵羊……不怀疑她就只能怀疑女佣有三只手。

这个老弟,无端端怎么把钱放在家里啊?这不是引人犯罪吗?或是他自己搞错了。但一千多元,不是几元的事情,怎么可能会弄错?

可要真的是女佣拿的,那家里就不再安全了。其实正常人都会怀疑是女佣……但目前没有证据。但家里没有人会拿,不是她就是小猫……

感叹钱这东西真的害人不浅。要是这世界不再需要钱了,那该多好。但人都是贪婪的……不过君子爱财,取之有道才是。看来我真的需要多长心眼……这个女佣不得不防。我很希望不是,但既然钱不是我拿的,家里唯一会动手的不是小猫就是她。小猫会偷钱吗?至少到现在,那么多年下来,我的现金她都没有碰。所以我还是相信小猫的。但相信归相信……相信不能当饭吃。钱毕竟是在家里失踪的……

还是等老弟回来再问清楚。若是今天早上才不见的,那必定不是小猫干的。

无论如何,出于不安,我把房里的现金挪了。这个世界真的很难相信任何人的……日防夜防,家贼难防。今天是一千元,明天呢……

白话朝廷:11亿的肉包子打狗要在行动党和反对党之间作选择实在不容易却又那么简单。理由非常单调~因为执政党高高在上,但治国实力却低低在下。也因为地位那么高,下面的声音听不进去而治国也不行,那么真正真实的改革就遥遥无期,苦日子就天长地久了。这不可取。然而反对党虽然地位低低在下,但治国的实力也一样是低低在下,间中还不乏如Chia Ti Lik这类恶心律师的野心勃勃,还包括了一大堆问题……治国本事儿在执政前都没有,问题却那么多,执政后更不敢奢望什么;也不可取。主要的是老子注重的不是你是哪派系的而是治国的实力,所以轻描淡写比较一下……真的要选择,从何选择?都不入流呗~

所以寄望有什么新的杰出派系蹦出来,那时就好办了。那顺理成章,实至名归就没问题了。目前保持中立是没错的啦~

我也不敢再寄望执政党能有什么作为……其实如今执政党的人才凋零,能不出事儿已经谢天谢地了。最近的国家预算案出炉,老男人眼巴巴看着百姓的11亿新币哗啦啦流入了巴士公司的口袋……真是莫名的无奈,的悲从中来。这根本就是变相加价嘛!要是我有11亿银子,把这白花花的银子存在政府的肚皮底下,那明天又不知会跑入那家公司的荷包内了。这些无能的公司,平日老是涨车资,那个无能的PTC老是让涨,结果SMRT(新加坡地跌公司)出了一大票事儿后,维修投资才8%~那些公司又不是亏大钱,如今注资买巴士成了世界新闻……政府的实力……如今就剩下出了问题就花银子速速摆平;你对政府期望越高失望更大。

现在的政局就是如此……莫名其妙。下一届不知道又哪几个活宝登场……这闹剧似乎永无止尽。当部长就李小龙总理一句话,什么人都能当部长,结果什么都办不好。有银子也不是这样花法~政府的‘壮举’如今世界头条,难道脸上就光彩了?如此治国之能,这支持率是上还是下?

老男人笑呵呵……这些部长可不便宜,乃全世界政界薪水最高之流……但表现也不好那么下流呀~

恕老男人直言,这滥竽充数也充得太过明显。明明没料却敢敢登大雅……会不会有点儿那么个‘那个’?虽然百姓愚蠢,一时半刻不会把政府投出去,但老这样搞流水账……薪水世界级的政府,能不能老男人开家空壳公司也给注入一、两个亿意思意思一下?那么多钱,怎么不给穷苦百姓算了。现在的物价高涨,也包括那些年莫名其妙的票价上涨。凭什么交通公司赚大钱还要国库捐?

应该是政府太无聊,和我们这些小老百姓开玩笑吧~

老男人希望屋价出问题,别聪明到又丢几个亿给私人发展商胡搞咯~要是治理就是简单的花银子摆平,不必年薪百万的,三岁小儿也能治国啦!

真的纳闷~

[Like A Rose] My biggest regret in life is probably losing Kate. She is gone and there is nothing that I can do. I am lovesick. So love can be a horrible disease at times, to some people, it’s permanent. I should have married her and fuck cared everything else. But I didn’t move; and when I tried, it’s no longer possible.

No one can substitute Kate. She is the one and only, and she’s lost. Her life completely changed. Probably her personality changed too.

I try not to think about her.

It is very hard. Everyday I must keep myself in check. It’s unfair to the other women, but Kate is special. I knew it when I first saw her. I tried to avoid… but I failed. Fate made us meet again.

Love can be a very tough shit to take. Gosh…

Kate has aged fast. I don’t care. I can’t care. It’s the feel that lingers, not her face… not her body… it’s her soul. I wanted her soul very much… just like Belle Swan to Edward Cullen. I can’t bear to see her age. It breaks my heart so badly I can barely breath. She is a mortal… Seeing her wither is such pain… so much pain that I refuse to confront her again. It only seems like yesterday… that we spoke at the bench in college. I don’t know why… my heart shook when I came close to her. I knew she is the One… she is Forever.

The pain is making me stronger than I never expected to be. Years of avoiding her… I have thought I was safe. How pitiful for my naive thought…

I must grow stronger… till I can free myself from the One. I am getting stronger… I am resisting her facebook. As long as we don’t cross paths again, I’d be ok. I miss her… so very much. But I’d withstand the cold… I have to. I have no choice. I can do it… every day, every hour, every min… every second.

Of all women in this fucking world… I have fallen in love with Kate.

I wish we have never met.

How to rescue the immune system

February 25, 2012 by admin 

In a study published in Nature Medicine, Loyola researchers report on a promising new technique that potentially could turn immune system killer T cells into more effective weapons against infections and possibly cancer.

 

The technique involves delivering DNA into the immune system’s instructor cells. The DNA directs these cells to overproduce a specific protein that jumpstarts important killer T cells. These killer cells are typically repressed in patients who have HIV or cancer, said JosA© A. Guevara-Patino, MD, PhD, senior author of the study. Guevara is an Associate Professor in the Oncology Institute of Loyola University Chicago Stritch School of Medicine.

Guevara and colleagues reported their technique proved effective in jumpstarting defective immune systems in immuno-compromised mice and in human killer T cells taken from people with HIV.

Guevara said a clinical trial in cancer patients could begin in about three years.

The study involved killer cells, known as CD8 T cells, and their instructor cells, known as antigen-presenting cells. The instructor cells instruct CD8 T cells to become killer T cells to kill infected cells or cancer cells — and to remain vigilant if they reencounter pathogens or if the cancer comes back.

In addition to getting instructions from the antigen-presenting cells, CD8 T cells need assistance from helper T cells to become effective killers. Without this assistance, the killer T cells can’t do their job.

In patients who have HIV, the virus destroys helper T cells. In cancer patients, helper T cells also are affected. Among a tumor’s insidious properties is its ability to prevent killer T cells from attacking tumors. It does this by putting helper T cells into a suppressed stage, limiting their ability to assist CD8 T cells, said Andrew Zloza, MD, PhD, one of the leading authors of the study.

In the study, snippets of DNA were delivered into skin instructor cells by a device known as a gene gun. The DNA directed the instructor cells to produce specific proteins, which act like molecular keys. When CD8 T cells interact with the instructor cells, the keys unlock the CD8 T cells’ killer properties — jumpstarting them to go out and kill pathogens and cancer cells.

With the use of this technique, the killer T cells would not need the assistance of helper T cells. So even if a tumor were to put the helper T cells in a suppressive cage, the killer T cells would still be able to go out and kill cancer cells. Researchers expect that future studies using the technique will make it applicable to many diseases, including cancer.

###

The study received major funding from the national office of the American Cancer Society, the Illinois chapter of the American Cancer Society and the National Institutes of Health.

Other authors are Frederick Kohlhapp (co-first author), Gretchen Lyons (co-first author), Jason Schenkel, Tamson Moore, Andrew Lacek, Jeremy O’Sullivan, Vineeth Varanasi, Jesse Williams, Michael Jagoda, Emily Bellavance, Amanda Marzo, Paul Thomas, Biljana Zafirova, Bojan Polic, Lena Al-Harthi and Anne Sperling.

Contact: Jim Ritter
jritter@lumc.edu
708-216-2445
Loyola University Health System

Source:http://www.breakthroughdigest.com/medical-news/how-to-rescue-the-immune-system/

I mentioned this in a ‘Notice’ but I reckon it is important enough to leave a permanent record of this paper in this blog. Other than physics, I am very much interested in biochemistry. I don’t really care if you understand what all those papers say, but they are important and I read Breakthrough Digest regularly to be updated of the latest ‘equipment’ for the body.

With this discovery, very soon… we can have a secondary immune system set up artificially… The need to fight HIV and Cancer can never be understated, and we need such scientific progresses to aid mankind because if we can defeat infections and cancers… there is really very little nature can do to kill you lest by an accident. I hope Singapore will keep itself abreast with such development and most importantly… be ready to introduce such wonderful advances into our lives.

[Jagged Alliance: Back In Action] After so many years, ‘Jagged Alliance’ is back in action! I am quite surprised to see the copies at Challenger the other day because I tried ‘Jagged Alliance 2’ and it was a great game. Too bad the new ‘Back In Action’ is only a nominee for the best game of the year. Honestly, it’s probably better than most 3D shooting games which I am getting bored of; seriously, ‘Jagged Alliance’ should be a best game of 2011…  I am glad I see ‘Back In Action’, and I am keen to get a copy. If you have not tried the game, try it.

I have watched some introductions about this game on Youtube and I do hope the promised in-game tutorial would be comprehensive enough. It’s basically running an army of mercenaries and playing a strategy cum tactical game taking bases after bases, and eventually to eliminate a ‘Queen’. Before Fallout 4 hits the market by don’t-know-when, ‘Jagged Alliance: Back In Action’ should promise hours and days and weeks of raw entertainment.

I actually prefer a turn-based ‘Jagged Alliance’, but this should be ok if the tutorial can get me start well enough. It’s been a long time since I last played ‘Jagged Alliance 2’ and this copy helps recall the fun I had that many years back. Oh… How time flies.

Just when I thought I would die of boredom… This is certainly good news. I enjoyed ‘Jagged Alliance 2’, I think I’d love ‘Jagged Alliance 3’.

This is Leon, who happens to have the most adorable giggles possible in this world. He is turning 3yo in a few months. I envy him… though I must say I used to be a baby too. LOL~ That was so long ago… He wasn’t in the nursery these few days. It is said that chicken pox is plaguing the nursery now, so just as well… Leon has been home for now because he got a slight fever a few days back.

I hope he can talk soon because I have always wanted to teach him chess.

Leon…

Hopefully, he’d be a good match. Boy, just go on laughing… all your fucking life. Are you also an immortal, Leon…? May my love guide you well.

He makes me wants to be a baby myself. Life was so much more simpler as a baby… all games… all the curiousities in the world…

Ignorance is such bliss.

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